Sputum characteristics of patients with severe COVID-19: report of two cases with immunocytochemical detection of SARS-CoV-2 spike proteinArticle Published on 2022-12-012022-11-15 Journal: Medical molecular morphology [Category] COVID19(2023년), SARS, 치료기술, [키워드] aggregation alveolar Analysis can be used CD68 Cell cells characteristics of patient chromatin COVID-19 cytological cytoplasmic definitive diagnosis double infection epithelial evaluated exclusion expression Herpe herpes simplex herpes simplex virus immunocytochemistry Inclusion infected cell Infection intranuclear multinuclear nuclear nuclei Patient performed pneumocyte positive protein A SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike SARS-CoV-2 spike protein severe COVID-19 simplex specimen sputum Sputum sample Sputum. staining These cells Treatment viral infection virus [DOI] 10.1007/s00795-022-00326-9 PMC 바로가기
Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adultsArticle Published on 2022-10-042022-11-16 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] Activation Adaptive immune response antibodies antibody BCG BCG vaccination benefit booster breadth CD4+ CD8+ T-cell changes changes in chromatin Combination COVID-19 vaccines Delta Effect effector memory eight elevated ENhance Epigenetic Evidence expressing greater Heterologous highlighting IL-1β IL-2 immune response Immunity in-depth analysis India marker memory T-cell response mutant NAb Neutralizing provide revaccination SARS-CoV-2 seronegative significantly higher subset T cell T-cell Response tested TNF-α TNF-α expression trained immunity. Tuberculosis vaccination Vaccine vaccine-induced immune response [DOI] 10.3389/fimmu.2022.985938 PMC 바로가기
Single-cell transcriptome analyses reveal distinct gene expression signatures of severe COVID-19 in the presence of clonal hematopoiesisArticle Published on 2022-10-012022-11-16 Journal: Experimental & Molecular Medicine [Category] 변종, 유전자 메커니즘, [키워드] analysis ChIP chromatin chromatin architecture classical monocytes clinical impact COVID-19 dissect element exacerbating exhibited facilitate Gene Expression gene expression signature Hematopoiesis highlight hyperinflammation IFN-γ immunological individual Inflammation inflammatory immune response Inflammatory responses interactions mechanism methylated mononuclear cells Patient Peripheral blood putative target gene Region Regulatory reported severe COVID-19 severe COVID-19 patients severity single-cell susceptibility Transcriptome with COVID-19 [DOI] 10.1038/s12276-022-00866-1 PMC 바로가기
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicryArticle Published on 2022-10-012022-11-16 Journal: Nature [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome Affect antiviral response attenuate caused chromatin Control coronavirus coronavirus disease COVID-19 Critical Deletion demonstrated disrupt Epigenetic function global pandemic Host host cell host cell response Infection mechanism mimicking molecular basis motif ORF8 ORF8 gene post-translational modification promote Protein provide recent Region Regulation required SARS-CoV-2 severity of COVID-19 suppress the SARS-CoV-2 transcriptional regulation transcriptional response viral genome Viral protein [DOI] 10.1038/s41586-022-05282-z PMC 바로가기
Catching BETs by virusesArticle Published on 2022-10-012022-11-16 Journal: Biochimica et biophysica acta. Gene regulatory mechanisms [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] acetylated acetylation being BET BRD4 bromodomain cellular chromatin component Critical docking domain envelope protein ET domain evade function Genome highlight Histones Host host cell innate immune response Interaction maintain mechanism Protein SARS-CoV-2 target transcriptional regulators viral infection Viral protein Viral proteins virus virus. viruses [DOI] 10.1016/j.bbagrm.2022.194859 PMC 바로가기
Single cell gene expression profiling of nasal ciliated cells reveals distinctive biological processes related to epigenetic mechanisms in patients with severe COVID-19Research article Published on 2022-09-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 신약개발, 유전자 메커니즘, 임상, [키워드] Activation addition analyses biological processe Cell cellular chromatin ciliated cell Clinical course COVID-19 disease DNA downregulation Epigenetic epithelial cell expand explain Gene expression profiling gene expression signature healthy control histone methylation Histones Interaction mechanism mechanisms membrane permeability Methylation miRNA misfolded proteins Mitochondria Mitochondrial function molecular nasal nasopharyngeal objective pathogenic mechanism pathway enrichment Patient patients with COVID-19 Regulation Regulatory Result reveal SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 miRNAs scRNAseq sequence severe COVID-19 Single-cell RNA sequencing Single-cell transcriptomics the patient upregulation were used [DOI] 10.1016/j.compbiomed.2022.105895 [Article Type] Research article
Repurposing the mitotic machinery to drive cellular elongation and chromatin reorganisation in Plasmodium falciparum gametocytes Research Published on 2022-08-272022-10-05 Journal: Nature Communications [Category] 신약개발, [키워드] cellular chromatin complex components cytoplasmic disrupt driven by Endoplasmic reticulum falciform involved kinetochore protein malaria membrane Microscopy microtubule organizing center microtubule-associated protein mitotic nuclear nuclear envelope nuclear membrane Plasmodium falciparum Prevent Protein Proteins repurposing [DOI] 10.1038/s41467-022-32579-4 [Article Type] Research
FACT subunit SUPT16H associates with BRD4 and contributes to silencing of interferon signalingFACT 소단위 SUPT16H는 BRD4와 연관되어 인터페론 신호 전달 억제에 기여합니다Article Published on 2022-08-262022-09-11 Journal: Nucleic Acids Research [Category] SARS, 유전자 메커니즘, [키워드] acetylated acetylation Activation Affect association BRD4 cause CBL0137 cells chromatin co-culture complex composed contribute demonstrated Depletion domain enzyme epithelial EZH2 gene transcription Genetic HDAC1 heterodimeric protein histone chaperone IFN IFN signaling IFNs infected cells Infection Influenza inhibit inhibitor interferon interferon signaling interferon-stimulated gene interferon-stimulated genes ISGs killing knockdown lysine mechanism Modification natural killer NK cells pharmacological promote promoter Protein protein stability regulate regulated reported RNAi SARS-CoV-2 shown Signaling SSRP1 subunit suppression SUPT16H Transcription treat viral infections virus-infected cell virus-infected cells viruses Zika [DOI] 10.1093/nar/gkac645 PMC 바로가기 [Article Type] Article
Nicotine in Combination with SARS-CoV-2 Affects Cells Viability, Inflammatory Response and Ultrastructural IntegritySARS-CoV-2와 결합된 니코틴은 세포 생존, 염증 반응 및 미세구조 완전성에 영향을 미칩니다Article Published on 2022-08-222022-09-12 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] A549 A549 cell analyzed caused Cell cellular damage characterized chromatin Combination COVID-19 cytokine production Cytokines Cytopathic effect cytopathic effects cytoplasmic cytosol cytotoxicity decrease dose Endoplasmic reticulum expression level extracellular space feature granules human lung human lung adenocarcinoma A549 cells IL10 IL6 IL8 infected with SARS-CoV-2 Inflammatory cytokine Inflammatory cytokines integrity LPS mechanism of action membrane rupture Modification modifications modulate necroptosis Nicotine poly(I:C) positive proinflammatory proinflammatory cytokines protective role pyroptosis pyroptosis. response SARS-CoV-2 TNFα Vero E6 cell were used [DOI] 10.3390/ijms23169488 PMC 바로가기 [Article Type] Article
Chromatin-Associated Molecular Patterns (CAMPs) in sepsis Reviews Published on 2022-08-122022-10-05 Journal: Cell Death & Disease [Category] 바이오마커, [키워드] cells chromatin damage-associated molecular pattern DAMPs DNA downstream endogenous molecule endogenous molecules Extracellular extracellular traps Histones immune response immune signaling pathways Inflammation mechanism of action mitigate mitochondrial molecular pattern nuclear DNA PAMPs pathogen pattern Pattern recognition receptors Proteins recognize RNA Sepsis terminology therapeutic approach tissue injury [DOI] 10.1038/s41419-022-05155-3 [Article Type] Reviews